Natural gas production is associated with emissions of several trace gases, some of them classified as air toxics. While volatile organic compounds (VOCs) have received much attention, hydrogen sulfide (H<sub>2</sub>S) can also be of concern due to the known health impacts of exposure to this hazardous air pollutant. Here, we present quantitative, fast time-response measurements of H<sub>2</sub>S using proton-transfer-reaction mass-spectrometry (PTR-MS) instruments. An ultra-light-weight PTR-MS (ULW-PTR-MS) in a mobile laboratory was operated for measurements of VOCs and H<sub>2</sub>S in a gas and oil field during the Uintah Basin Winter Ozone Study (UBWOS) 2012 campaign. Measurements of VOCs and H<sub>2</sub>S by a PTR-MS were also made at the Horse Pool ground site in the Uintah Basin during UBWOS 2013. The H<sub>2</sub>S measurement by PTR-MS is strongly humidity dependent because the proton affinity of H<sub>2</sub>S is only slightly higher than that of water. The H<sub>2</sub>S sensitivity of PTR-MS ranged between 0.6–1.4 ncps ppbv<sup>−1</sup> during UBWOS 2013. We compare the humidity dependence determined in the laboratory with in-field calibrations and determine the H<sub>2</sub>S mixing ratios for the mobile and ground measurements. The PTR-MS measurements at Horse Pool are evaluated by comparison with simultaneous H<sub>2</sub>S measurements using a PTR time-of-flight MS (PTR-ToF-MS) and a Picarro cavity ring down spectroscopy (CRDS) instrument for H<sub>2</sub>S / CH<sub>4</sub>. On average 0.6 ± 0.3 ppbv H<sub>2</sub>S was present at Horse Pool during UBWOS 2013. The correlation between H<sub>2</sub>S and methane enhancements suggests that the source of H<sub>2</sub>S is associated with oil and gas extraction in the basin. Significant H<sub>2</sub>S mixing ratios of up to 9 ppmv downwind of storage tanks were observed during the mobile measurements. This study suggests that H<sub>2</sub>S emissions associated with oil and gas production can lead to short-term high levels close to point sources, and elevated background levels away from those sources. In addition, our work has demonstrated that PTR-MS can make reliable measurements of H<sub>2</sub>S at levels below 1 ppbv.